Biochemistry

Gerald Hazelbauer, Chair
College of Agriculture, Food and Natural Resources
117 Schweitzer Hall
Phone: (573) 882-4845
Fax: (573) 882-5635

A course of study in the Department of Biochemistry emphasizes the application of chemical principles to biological systems and leads to the Bachelor of Science in Biochemistry. The program requires rigorous course work in the basic sciences, culminating with a two course capstone experience of discipline specific problems and laboratory techniques. Students are encouraged to gain research experience through independent projects in faculty labs. The biochemistry degree prepares students for further study in graduate or professional school or for a career in biochemistry, biotechnology or the biological, chemical or medical sciences.

Professor L. Beamer**, D. Burke**, S. J. Chen*, S. Deutscher**, D. Emerich**, W. Folk**, K. Gates*, T. Guilfoyle**, M. Hannink**, G. Hazelbauer**, M. Henzl**, D. Lubahn**, T. Mawhinney**, B. McClure**, S. Peck**, M. Petris**, T. Quinn**, L. Randall**, R. M. Roberts**, S. Sarafianos**, F. Schmidt**, K. Sharma**, G. Stacey**, L. Sumner**, J. Tanner*, J. Thelen**, P. Tipton**, R. Tsika**, S. Van Doren**, J. Wall**, G. Weisman**, S. Zhang**
Associate Professor P. Cornish**, A. Heese**, G. King*, M. Martin*, B. Peculis*, C. Phillips*, M. Siegel*,  X. Zou**
Assistant Professor X. Heng**, A. Koo**
Research Associate Professor L. Erb*
Research Assistant Professor Z. Lei, B. Mooney, V. Mossine, T. White*
Adjunct Professor J. Miernyk**
Associate Teaching Professor S. Freyermuth
Assistant Teaching Professor C. Lee, M. Pennella

College of Agriculture, Food and Natural Resources; School of Medicine
117 Schweitzer Hall
(573) 882-4846
http://www.biochem.missouri.edu/

Director of Graduate Studies: Thomas Quinn

Biochemistry at the University of Missouri is a division of the College of Agriculture, Food and Natural Resources and a department of the School of Medicine. As a nationally ranked top 10 biochemistry department among public medical schools, we offer outstanding training that help students achieve their goals. We have 39 core faculty members and approximately 10 additional members, all of whom are available to mentor students in biochemistry. Nearly all facets of contemporary biochemical research are represented in their collective research interests. Our highly interactive program is an integral part of a campus-wide network of research programs including life sciences, genetics, nutrition, plant biochemistry and structural biology.

Interdisciplinary Area Programs

The graduate programs of the Department of Biochemistry prepare students for professional careers in academic institutions, industry and government. The Department of Biochemistry is administered by the College of Agriculture, Food and Natural Resources and the School of Medicine. It provides a great range of opportunities for multidisciplinary study in plant, animal and microbial biochemistry, molecular biology, structural biology, and chemical biology.

Faculty Research

Virtually every important area of biochemistry and molecular biology is represented among the research interests of the faculty. These interests focus on plant biochemistry, hormonal control of plant and animal-cell metabolism, growth-factor structure and function, enzyme reaction mechanisms, biochemistry of development, biochemistry of human disease, lipid and carbohydrate metabolism, molecular biology, analytical biochemistry, proteomics, systems biochemistry, and structural biochemistry.

Facilities

The department has modern, well-equipped laboratories in the Life Sciences Center, Schweitzer Hall, Schlundt Annex, and Stephens Hall. Additional faculty are housed in the Animal Sciences Research Center, Chemistry Building, Dalton Cardiovascular Research Center, Mason Eye Institute, and the Truman Veterans Hospital.

Plans of Study

All students participate in individually planned research programs and have a supervised teaching experience along with course work. Students are expected to complete a program of courses in biochemistry and selected courses in modern biology and chemistry.

Careers

Biochemistry at the University of Missouri provides world-class training that can open the door to a wide variety of career opportunities in the life sciences. Our graduates have career opportunities available in academia, industry, agriculture or medicine.

Required Application Materials

All pre-requisites and application materials must be submitted by the annual deadline.

MD/PhD in Biochemistry Dual Degree Program

Students already accepted into the School of Medicine at MU may apply to the Department for acceptance into the MD/PhD program. Students matriculating in the MD/PhD degree program must complete degree requirements of both the School of Medicine and the Graduate School. For information and for application forms, email gradprogram@missouri.edu or write the Director of Graduate Admissions in Biochemistry, 117 Schweitzer Hall, Columbia, MO 65211, or visit the website http://www.biochem.missouri.edu.

BIOCHM 1090: Introduction to Biochemistry

Fundamental concepts in biochemistry and molecular biology: structure function relationships, reactivity, thermodynamics, gene expression. Professional skills for biomedical careers. Graded on A-F basis only.

Credit Hours: 3
Prerequisites or Corequisites: CHEM 1320
Prerequisites: MATH 1100 or MATH 1160 or MATH 1500 and Freshman or Sophomore standing


BIOCHM 1094: Introductory Biochemistry Laboratory

Techniques course involving analytical experiments with carbohydrates, lipids, proteins, nucleic acids; use of instrumentation in biochemistry; purification and kinetics of enzymes, PCR and cloning. Graded on A-F basis only.

Credit Hours: 2
Prerequisites: BIOCHM 1090; Biochemistry majors only


BIOCHM 2110: The Living World: Molecular Scale

Survey of modern biochemistry and biotechnology. Structure and function of DNA, proteins, lipids and carbohydrates. The role of biopolymers in life processes and everyday living is emphasized.

Credit Hours: 3
Prerequisites: for non-Biochemistry majors only


BIOCHM 2112: Biotechnology in Society

Biotechnology in a social context covers three areas: introduction to terminology and concepts, specific biotechnological applications to modern problems, and ethical questions.

Credit Hours: 3
Prerequisites: for non-biochemistry majors only


BIOCHM 2480: Introduction to Macromolecular Structure and Function

The function of biochemical macromolecules is directly related to their structure. The three-dimensional structures of proteins, nucleic acids, polysaccharides and membranes are each explored in the context of their functions and their microenvironments within living organisms. Graded on A-F basis only.

Credit Hours: 2
Prerequisites: C- or higher in BIOCHM 1090; CHEM 2100
Corequisites: CHEM 2110


BIOCHM 2484: Macromolecular Techniques Laboratory

The laboratory experiments include DNA isolation, DNA cloning, PCR, plasmid transformation, protein expression, affinity-tagged chromatography, SDS-polyacrylamide gel electrophoresis, enzyme isolation, enzyme assay, buffer preparation, and Michaelis-Menten kinetics. Graded on A-F basis only.

Credit Hours: 2
Prerequisites: sophomore standing; restricted to Biochemistry majors only


BIOCHM 2484H: Macromolecular Techniques Laboratory - Honors

The laboratory experiments include DNA isolation, DNA cloning, PCR, plasmid transformation, protein expression, affinity-tagged chromatography, SDS-polyacrylamide gel electrophoresis, enzyme isolation, enzyme assay, buffer preparation, and Michaelis-Menten kinetics. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: sophomore standing; Biochemistry majors only. Honors eligibility required


BIOCHM 2484HW: Macromolecular Techniques Laboratory - Honors/Writing Intensive

The laboratory experiments include DNA isolation, DNA cloning, PCR, plasmid transformation, protein expression, affinity-tagged chromatography, SDS-polyacrylamide gel electrophoresis, enzyme isolation, enzyme assay, buffer preparation, and Michaelis-Menten kinetics. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: sophomore standing; Biochemistry majors only. Honors eligibility required


BIOCHM 2950: Undergraduate Research in Biochemistry

Research for students in which independent research is less than 50% of total. Graded on S/U basis only.

Credit Hour: 1-3
Prerequisites: departmental consent


BIOCHM 3630: General Biochemistry

Survey of biochemistry; static/dynamic aspects of carbohydrates, lipids, proteins, nucleic acid. Discussion of metabolic pathways, energy production, and metabolic regulatory mechanism.

Credit Hours: 3
Prerequisites: CHEM 2030 or CHEM 2100


BIOCHM 4001: Topics in Biochemistry

Experimental courses; highly specialized topics taught infrequently or courses taught by visiting professors.

Credit Hour: 1-99


BIOCHM 4120: Medicinal Plant Science

Presentation of core topics, including an overview of plant groups with medicinal properties, botanical nomenclature, important biochemical pathways, exposure to journals, texts, and online databases that facilitate evidence-based research involving medicinal plants. Content of world-wide application. Has an international flavor. The course facilitates students to be independent learners and critical thinkers in this important knowledge area (of value to diverse academic backgrounds). The important role of collaborative inter-disciplinary studies will also be emphasized. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: CHEM 1100 or CHEM 1320
Recommended: BIO_SC 1200 or BIO_SC 1500 or BIOCHM 1090


BIOCHM 4270: Biochemistry

(cross-leveled with BIOCHM 7270). First semester of comprehensive biochemistry course: metabolic pathways, amino acids/proteins, carbohydrates, lipids, nucleic acids, kinetics, energy requirements, metabolic regulation in living cells.

Credit Hours: 3
Prerequisites: CHEM 2110


BIOCHM 4272: Biochemistry

(cross-leveled with BIOCHM 7272). Second semester of a comprehensive biochemistry course, including metabolism of carbohydrates, fatty acids, steroids, amino acid synthesis and metabolism, molecular genetics, hormones, photosynthesis and integrated metabolism.

Credit Hours: 3
Prerequisites: C- or higher in BIOCHM 4270


BIOCHM 4300: Physical Chemistry of Biological Systems

To present fundamental principles of physical chemistry in the context of the structure and function of biological macromolecules. Graded on A-F basis only.

Credit Hours: 3
Prerequisites or Corequisites: BIOCHM 4270


BIOCHM 4376: Computer Assisted Sequence Analysis and Molecular Modeling

(cross-leveled with BIOCHM 7376). Employs the use of computer-based interactive molecular graphics and sequence analysis software to analyze the three dimensional structures of macromolecules.

Credit Hours: 3
Prerequisites: CHEM 2110


BIOCHM 4385: Problems in Biochemistry


Credit Hour: 1-3
Prerequisites: departmental consent


BIOCHM 4460: Cancer Biology

(same as BIO_SC 4460; cross-leveled with BIOCHM 7978, BIO_SC 7978). Cancer, cell biology, genetics, biochemistry.

Credit Hours: 3
Prerequisites: BIOCHM 4272, BIO_SC 2300 and BIO_SC 2200


BIOCHM 4510: Single Molecule Biophysics

(same as PHYSCS 4510; cross-leveled with BIOCHM 7510, PHYSCS 7510). The course provides an overview of the biophysics of enzymes, nucleic acids and the cytoskeleton. Topics covered will include diffusion, molecular motors, polymerization and the cytoskeleton and the polymer properties of nucleic acids and microtubules.

Credit Hours: 3
Prerequisites: PHYSCS 2760


BIOCHM 4940: Internship in Biochemistry

Field-based learning experience combining study, observation, and employment with a business, organization, or governmental agency. The internship provides opportunities to apply skills, concepts and theories about biochemistry in a practical context. The student intern, internship supervisor, and university coordinator will develop an individualized internship plan. Graded on S/U basis only.

Credit Hour: 1-6
Prerequisites: instructor's consent
Recommended: junior standing


BIOCHM 4950: Advanced Undergraduate Research in Biochemistry

Research credit for students doing an independent research project under the guidance of a faculty member. Project must be arranged by student and faculty member prior to registration. Graded on A-F basis only.

Credit Hour: 1-3
Prerequisites: departmental consent


BIOCHM 4964: Industrial Internship with ABC Laboratories

This 5-credit course is a school and field-based learning experience combining the study, observation, and employment with ABC Laboratories in Columbia, MO. The internship provides opportunities to apply skills, concepts and theories about biochemistry and analytical chemistry in a practical context. The purpose of the internship experience is to provide the intern with the opportunity to develop knowledge and skills deemed desirable for a career in the biotechnology industries. During the time indicated in this agreement for the internship experience, the intern is expected to become a productive employee of ABC Laboratories. This course will provide technical instruction on commonly used laboratory skills and instrumentation at the University of Missouri followed by technical instruction on software and instrumentation at ABC Laboratories. After the training period, the interns will have the opportunity to work at ABC Laboratories full time for the summer.

Credit Hours: 5
Prerequisites or Corequisites: BIOCHEM 4272, CHEM 3200
Prerequisites: BIOCHM 1090, BIOCHM 2484, BIOCHM 4270


BIOCHM 4970: Senior Capstone in Biochemistry

Problem-based course on fundamental concepts of biochemistry. Requires written and oral presentations. One of two capstone courses required for biochemistry majors. Graded on A-F basis only.

Credit Hours: 2
Prerequisites: Departmental consent required
Recommended: Corequsite of BIOCHM 4974


BIOCHM 4974: Biochemistry Laboratory

(cross-leveled with BIOCHM 7274). Techniques course involving analytical experiments with carbohydrates, lipids, proteins, nucleic acids; use of instrumentation in biochemistry; purification and kinetics of enzymes. One of two capstone courses required for biochemistry majors.

Credit Hours: 5
Prerequisites or Corequisites: BIOCHM 4272
Corequisites: BIOCHM 4970


BIOCHM 4974W: Biochemistry Laboratory - Writing Intensive

(cross-leveled with BIOCHM 7274). Techniques course involving analytical experiments with carbohydrates, lipids, proteins, nucleic acids; use of instrumentation in biochemistry; purification and kinetics of enzymes. One of two capstone courses required for biochemistry majors.

Credit Hours: 5
Prerequisites or Corequisites: BIOCHM 4272
Corequisites: BIOCHM 4970


BIOCHM 4996H: Honors Thesis Research in Biochemistry

Laboratory research for honors students doing an honors thesis research project in their final two semesters. Enrollment limited to Honors eligible students with senior standing who have CAFNR honors approval. Graded on A-F basis only.

Credit Hour: 1-3
Prerequisites: departmental consent


BIOCHM 7085: Problems in Biochemistry

Problems in Biochemistry.

Credit Hour: 1-6
Prerequisites: Consent of Director of Graduate Studies required


BIOCHM 7110: Maps in Medicine Summer Institute

Lab/lecture course in which high school teachers gain knowledge of two innovative, inquiry-based programs, Mapping Health and Mapping Cell Fate, that focus on influenza and developmental biology and Missouri science standards for biology and health. Graded on S/U basis only.

Credit Hours: 2
Prerequisites: departmental consent


BIOCHM 7270: Biochemistry

(cross-leveled with BIOCHM 4270). First semester of comprehensive biochemistry course: metabolic pathways, amino acids/proteins, carbohydrates, lipids, nucleic acids, kinetics, energy requirements, metabolic regulation in living cells.

Credit Hours: 3
Prerequisites: CHEM 2110


BIOCHM 7272: Biochemistry

(cross-leveled with BIOCHM 4272). Second semester of a comprehensive biochemistry course, including metabolism of carbohydrates, fatty acids, steroids, amino acid synthesis and metabolism, molecular genetics, hormones, photosynthesis and integrated metabolism.

Credit Hours: 3
Prerequisites: BIOCHM 7270


BIOCHM 7274: Biochemistry Laboratory

Techniques course involving analytical experiments with carbohydrates, lipids, proteins, nucleic acids; use of instrumentation in biochemistry; radioisotope tracers in metabolism; isolation, purification and kinetics of enzymes.

Credit Hours: 5
Corequisites: concurrent enrollment in BIOCHM 7270


BIOCHM 7376: Computer Assisted Sequence Analysis and Molecular Modeling

(cross-leveled with BIOCHM 4376). This course uses advanced computer graphics and computational techniques to analyze protein and nucleic acid sequences and their three-dimensional structures.

Credit Hours: 2
Prerequisites: CHEM 2110


BIOCHM 7510: Single Molecule Biophysics

(same as PHYSCS 7510; cross-leveled with BIOCHM 4510, PHYSCS 4510). The course provides an overview of the biophysics of enzymes, nucleic acids and the cytoskeleton. Topics covered will include diffusion, molecular motors, polymerization and the cytoskeleton and the polymer properties of nucleic acids and microtubules.

Credit Hours: 3
Prerequisites: PHYSCS 2760


BIOCHM 7978: Cancer Biology

(same as BIO_SC 7978). The course will cover major molecular and cellular aspects of cancer. Students will read original research articles, present overviews and lead class discussions.

Credit Hours: 3
Prerequisites: BIOCHM 4270, BIO_SC 2300 and BIO_SC 4976


BIOCHM 8060: Ethical Conduct of Research

(same as BIO_SC 8060). Discussion of ethical issues in biological research, including the rules and conventions for appropriate research conduct. Graded on S/U basis only.

Credit Hour: 1


BIOCHM 8090: Research in Biochemistry

Research in biochemistry for qualified students, with counsel of faculty. Includes preparation of dissertation. Graded on a S/U basis only.

Credit Hour: 1-99
Prerequisites: Consent of Director of Graduate Studies required


BIOCHM 8120: Advanced Medicinal Plant Science

Presentation of core topics in pharmacognosy, including an overview of plant groups with medicinal properties, essentials of botanical nomenclature, Overview of pharmacological activities of plant-sourced products and evidence-based research, phytochemical variation and significance, important biochemical pathways, origins of secondary metabolites, some major groups of phytochemicals, observations on economic and social trends in the use of medicinal plant products in developed and developing countries, overview of modern technology, high throughput screening, bioinformatics. Considerable exposure to key articles in journals, based on internationally accepted text (Trease & Evans), exposure to online databases - all sources of information that facilitate evidence-based research involving medicinal plants. Content of world-wide application. Has considerable international flavor and directly applicable to medicinal flora world-wide. The course facilitates students to be independent learners and critical thinkers in this important knowledge area (of value to diverse academic backgrounds). The important role of collaborative inter-disciplinary studies is also emphasized. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: CHEM 1100 or CHEM 1320 or BIOCHM 1090 and BIO_SC 1200 or BIO_SC 1500 or the equivalent of these courses for non-MU students
Recommended: A Freshman level course in the Life Sciences or General Botany will also be advantageous but not essential


BIOCHM 8240: Introduction to Graduate Biochemistry I

Introduction to biochemistry for life science graduate students. Core course for Biochemistry students. Structures and interactions of biological macromolecules including thermodynamics, binding, enzyme action and biological membranes as well as techniques of analysis and structure determination.

Credit Hours: 4
Prerequisites: Undergraduate organic chemistry plus undergraduate biochemistry or molecular biology, their equivalent or permission of instructor


BIOCHM 8260: Macromolecular Systems Integration

To introduce graduate students to biochemistry at the graduate level with particular emphasis on genomics/gene expression and replication; proteomics/cell signaling and metabolism. Course graded on A-F basis only.

Credit Hours: 4
Prerequisites: BIOCHM 8240


BIOCHM 8360: Nutritional Biochemistry of Carbohydrates

(same as NUTRIT 8360 and NEP 8360). Current concepts with in-depth coverage of selected examples of key regulatory steps controlling carbohydrate metabolism; emphasizing molecular mechanisms. Based entirely on research literature and taught in a tutorial format.

Credit Hours: 3
Prerequisites: BIOCHM 7272


BIOCHM 8362: Introduction to Plant Metabolism

(same as PLNT_S 8362 and BIO_SC 8362). This course is part of a series that aims to provide a solid conceptual foundation in interdisciplinary plant biology for graduate students with a research emphasis in plant biology. This course examines the basic concepts and techniques used to understand plant metabolism. Graded on A-F basis only.

Credit Hours: 2


BIOCHM 8365: Introduction to Molecular Cell Biology

(same as BIO_SC 8365 and PLNT_S 8365). This course is part of a series that aims to provide a solid conceptual foundation in interdisciplinary plant biology for graduate students with a research emphasis on plant biology. This course examines the basic concepts and techniques used to understand molecular cell biology. Graded on A-F basis only.

Credit Hours: 2


BIOCHM 8390: Molecular Biology of Mineral Nutrition

(same as NUTRIT 8390 and NEP 8390). Current concepts of metal ion transport, intracellular metal trafficking and metal-dependent regulation of gene expression. Based entirely on research literature and taught in a tutorial format.

Credit Hours: 3
Prerequisites: BIOCHM 7272 and a 4000-level nutrition course


BIOCHM 8430: Physical Biochemistry

Physical concepts underlying a variety of physical chemical methods as they apply to biochemical research.

Credit Hours: 3
Prerequisites: BIOCHM 7272 and CHEM 3300


BIOCHM 8432: Enzymology and Metabolic Regulation

A basic introduction to the study of enzymes and their role in intermediary metabolism. Topics include enzyme kinetics, mechanisms of enzymatic catalysis and control of metabolic pathways.

Credit Hours: 3
Prerequisites: BIOCHM 7272


BIOCHM 8434: Signaling in Molecular Cell Biology

The objective of this course is to provide important foundations in cellular signaling in the context of biochemistry and cell biology for first and second year graduate students. The course focuses on cell-to-cell communication and intracellular signaling via different classes of cell surface receptors using specific receptor paradigms from human, other animals, plants, yeast and E.coli. Primary literature will be used for in-class discussions and homework assignments to highlight key experiments and introduce students to relevant experimental techniques. Graded on A-F basis only.

Credit Hours: 3
Recommended: BIO_SC 2300, BIOCHM 4270


BIOCHM 8438: Nutrient Regulation of Gene Expression

(same as AN_SCI 8438, NUTRIT 8438, and NEP 8438). Current concepts with in-depth coverage of several minerals that illustrate themes in molecular mineral nutrition. Based entirely on research literature and taught in a tutorial format.

Credit Hours: 3
Prerequisites: BIOCHM 7272 and a 4000-level nutrition course


BIOCHM 8450: Rotation Research

Introductory laboratory research. Graded on A-F basis only. Normally 1 hour per advisor per semester, two-1 hour sections can be taken per semester.

Credit Hour: 1-2


BIOCHM 9001: Topics in Biochemistry

Experimental courses, highly specialized topics taught infrequently or courses taught by visiting professors.

Credit Hour: 1-9


BIOCHM 9085: Problems in Biochemistry

Problems in Biochemistry

Credit Hour: 1-6


BIOCHM 9087: Seminar in Biochemistry

Review of current literature; individual presentation of research or classical science topics.

Credit Hour: 1


BIOCHM 9090: Research in Biochemistry

Research in biochemistry for qualified students, with counsel of faculty. Includes preparation of dissertation. Graded on a S/U basis only.

Credit Hour: 1-99


BIOCHM 9430: Molecular Biology I

(same as MICROB 9430). Detailed examination of current fundamental concepts of molecular genetics of bacteria, bacteriophages and yeast. Experimental approaches to analysis of the physical structures of genomic nucleic acids, the biochemistry and genetics of mutations, replication, gene transfer and gene expression will be examined in depth from reports in the current literature.

Credit Hours: 4


BIOCHM 9432: Molecular Biology II

(same as MICROB and BIO_SC 9432) Detailed experimental analysis of eukaryotic cellular and molecular biology relevant to cellular and viral gene expression, post-transcriptional and post-translational modifications and genome replication. Models for developmental genetic analysis and genetic determinants controlling developmental processes utilizing the current literature will be examined.

Credit Hours: 4


BIOCHM 9462: Hormone Action

A lecture course with weekly assigned readings. Topics will include: a description of selected polypeptide, steroid and other hormones and their biological effects; receptors; second messengers; protein phosphorylation in hormone mediation; growth factors; cellular oncogenes.

Credit Hours: 2
Prerequisites: BIOCHM 7272


BIOCHM 9466: Plant Biochemistry

Emphasizes biochemistry unique to plants; biochemical events plants share with other organisms discussed, compared. Photosynthesis, metabolism, composition, compartmentation, regulation of biochemical events included.

Credit Hours: 3
Prerequisites: BIOCHM 4270


BIOCHM 9468: Molecular Biology of Plant Growth and Development

(same as BIO_SC 9468). Molecular biology of plant hormones, signal transduction, environmental signals.

Credit Hours: 3


BIOCHM 9470: Analytical Biochemistry--Chromatography

Principles, experimental design, capabilities, limitations, and applications of the general field of chromatography of biologically important molecules. Eight (2-hour) lectures, eight (4-hour) labs. Four weeks.

Credit Hours: 2


BIOCHM 9472: Analytical Biochemistry--Mass Spectrometry

Instrumentation, fragmentation mechanisms, interpretation of spectra, combined gas chromatography--mass spectrometry. Eight (2-hour) lectures, eight (4-hour) labs.

Credit Hours: 2