Biological Engineering

J. Tan, Chair
College of Engineering
College of Agriculture, Food and Natural Resources
215 Agricultural Engineering Building
(573) 882-7044
TanJ@missouri.edu

Recognizing the immense promise of bioengineering and the unique position of Mizzou for a strong bioengineering program, the College of Agriculture, Food and Natural Resources (CAFNR) and the College of Engineering (CoE) joined forces to form the Department of Bioengineering* (BE).

Bioengineering unites existing faculty and infrastructure from both colleges. CoE contributes biomedical engineering capabilities while CAFNR brings strengths in bioprocess and bioenvironmental engineering.


*The Department of Biological Engineering became Bioengineering in 2013.  Courses and degree programs are still listed as Biological Engineering at this time.

Primary Faculty

Professors K. D. Gillis**, S. A. Grant**, J. Tan**, A. L. Thompson**, G. Yao**
Associate Professors S. Ding**, S. C. Borgelt*, L. Gu**, W. A. Jacoby**, R. Kannan**, S. Sengupta**
Assistant Professors C. Costello*, H. Hunt*, F. M. Pfeiffer*
Professor Emeritus F. H. Hsieh

Affiliated Faculty

Professors D. Brune**, C. S. Cutler*, M. Davis**, M. W. Downs*, G. Forgacs*, S. Gangopadhyay**, M. Hill**,  T. Hwang**, K. V. Katti**, M. L. Katz*, A. McClellan**, G. Meininger**, S. Nair**, E. J. Sadler*, L. G. Schumacher*, S. Segal*, K. A. Sudduth**, G. Suppes*, J. Viator**, E. Vories*
Associate Professors D. E. Baker*, T. M. Guess**, J. W. Kwon*, H. Li*
Assistant Professors M. Bernards*, P. V. Cornish**, T. T. Lim*,  L. A. Martinez-Lemus**, L. Polo-Parada**, R. A. White*, J. Zulovich*

*

Graduate Faculty Member - membership is required to teach graduate-level courses, chair master's thesis committees, and serve on doctoral examination and dissertation committees.

**

Doctoral Faculty Member - membership is required to chair doctoral examination or dissertation committees.  Graduate faculty membership is a prerequisite for Doctoral faculty membership.

Advising and Scholarship Contacts
Steve Borgelt, Undergraduate Director
254 Agricultural Engineering Building

Jean Gruenewald, Advising and Scholarship Coordinator
257 Agricultural Engineering Building
(573) 882-4659
gruenewaldj@missouri.edu

Biological engineering is a science-based engineering discipline that integrates engineering and biological sciences in one curriculum. The MU biological engineering program is a broadly-based curriculum that prepares students for careers in three areas:

  • Biomedical engineering (including pre-medicine)
  • Bioprocess engineering
  • Bioenvironmental engineering

Biological engineering graduates are hired by biotechnology, medical, pharmaceutical, food and agricultural companies, and by government agencies. Some attend graduate and medical schools. Graduates are well prepared to take the Fundamentals of Engineering exam during their senior year, which is the first step toward obtaining a Professional Engineer license.

The Bachelor of Science with a major in Biological Engineering (BS BE) program at MU is accredited by the Engineering Commission of ABET, www.abet.org. The biological engineering curriculum was developed to meet the mission, program objectives and student outcomes described below.

Mission and Objectives

The department mission is to educate biological engineers to integrate engineering and biological sciences in the contexts of health, sustainability and environmental stewardship, thus preparing them for productive careers characterized by continual professional growth.

Program Educational Objectives

The undergraduate program leads to a Bachelor of Science degree in Biological Engineering, producing graduates who will, within 3-5 years:

  1. Show proficiency in quantitative analysis, engineering design and development.
  2. Interact effectively with life science and other professionals.
  3. Leverage principles of biological and engineering sciences for the design and development of innovative systems.
  4. Exhibit professionalism as they continually add value to their chosen field of endeavor.
  5. Succeed in advanced study in engineering, medicine or other fields, if pursued.


Student Outcomes

By the time of graduation, Biological Engineering students will possess:

a.    An ability to apply knowledge of mathematics, science and engineering;

b.    An ability to design and conduct experiments, as well as to analyze and interpret data;

c.    An ability to design a system, component, or process to meet desired needs within realistic constraints such as economic, environmental, social, political, ethical, health and safety, manufacturability, and sustainability;

d.    An ability to function on multi-disciplinary teams;

e.    An ability to identify, formulate and solve engineering problems;

f.     An understanding of professional and ethical responsibility;

g.    An ability to communicate effectively;

h.    The broad education necessary to understand the impact of engineering solutions in a global, economic, environmental, and societal context;

i.      A recognition of the need for, and an ability to engage in, life-long learning;

j.     A knowledge of contemporary issues;

k.     An ability to use the techniques, skills, and modern engineering tools necessary for engineering practice;

l.      An ability to integrate engineering and biological sciences to develop systems and processes for improved health, bio-resource utilization, and environmental protection.


Exploratory Course

Students who want to learn more about the field should take BIOL_EN 1000 Introduction to Biological Engineering.

Department of Biological Engineering
254 Agricultural Engineering Building
Columbia, MO 65211-5160
(573) 882-7044
http://bioengineering.missouri.edu/

Director of Graduate Studies: Gang (Gary) Yao

About Biological Engineering

Recognizing the immense promise of bioengineering and the unique position of MU for a strong bioengineering program, the College of Agriculture, Food and Natural Resources (CAFNR) and the College of Engineering (CoE) joined forces to form the Department of Biological Engineering (BE). BE unites existing faculty and infrastructure from both colleges. CoE contributes biomedical engineering capabilities while CAFNR brings strengths in bioprocess and bioenvironmental engineering. Biological engineering confers both masters and doctoral degrees to students who satisfy the general requirements of the Graduate School and the specific requirements for the masters degree and the doctoral degree of the Department of Biological Engineering.  A Biomechanics Proficiency Area has recently been added.

Master in Engineering

A student may also choose to complete a Master of Engineering degree with a focus in Biological Engineering.  See the Master of Engineering page for requirements.

Thesis Research and Funding

Research assistantships are available to qualified graduate students. Thesis research may emphasize bioprocessing, biomedical engineering, environmental engineering or precision agriculture. Laboratories are well equipped for research in biomaterials, biomedical optics, bioprocessing, biosensors, computer vision, electrophysiology, food extrusion, properties of biological and food materials, process control, GIS, precision agriculture, water quality, wetlands, chemical application technology, soil physics, hydrology and renewable energy.

BIOL_EN 1000: Introduction to Biological Engineering

For first semester engineering students. Develop appreciation for professional engineering. Students will participate with senior design students to conceptualize a case-study problem.

Credit Hour: 1-2


BIOL_EN 2000: Professional Development in Engineering

A review of professional opportunities, registration, ethics, and societies.

Credit Hour: 1-2
Prerequisites: sophomore standing


BIOL_EN 2080: Introduction to Programming for Engineers

This course teaches how to write scientific programs for analysis of data and simulation of physical phenomena using Matlab. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: MATH 1500


BIOL_EN 2180: Engineering Analysis of Bioprocesses

Material and Energy Balances. Integrating principles of physics, chemistry and mathematics to analyze steady state and transient biological/biomedical processes. Graded on A-F basis only.

Credit Hours: 3
Recommended: MATH 1700, CHEM 1320, PHYSCS 2750


BIOL_EN 3001: Topics in Biological Engineering

Current and new technical developments in biological engineering.

Credit Hours: 3
Prerequisites: instructor's consent


BIOL_EN 3050: Environmental Control for Biological Systems

Systems for controlling the physical environments (heat, moisture, light, contaminating organism, chemicals) for plant and animal systems including livestock, aquacultures, crops and agricultural products.

Credit Hours: 3
Prerequisites: ENGINR 2300 and MATH 4100


BIOL_EN 3070: Biological Fluid Mechanics

Basic principles of fluid mechanics applied to transport processes in biological systems. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: PHYSCS 2750 and MATH 1700


BIOL_EN 3075: Introduction to Materials Engineering

Course covers concepts and techniques in materials engineering from an engineering design perspective, materials requirements for design, and fundamentals; intended for undergraduate engineering students. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: MATH 2300, ENGINR 1200, ENGINR 2200
Corequisites: One of the following BIOL_EN 3180, CH_ENG 3261, MAE 4231, MAE 4300, or instructor consent


BIOL_EN 3170: Biomaterials

Engineering sciences and design will be leverage for the study and design of biomaterials. Understanding the structure-property relationship between biomaterials and tissue will be addressed for implant design.

Credit Hours: 3
Corequisites: BIOL_EN 2180, ENGINR 2200 or instructor's consent


BIOL_EN 3180: Heat and Mass Transfer in Biological Systems

Principles of heat and mass transfer and their applications in biomedical, bioenvironmental, and bioprocessing engineering.

Credit Hours: 3
Prerequisites or Corequisites: ENGINR 2300 or CH_ENG 3261
Prerequisites: BIOL_EN 2180 or CH_ENG 2225


BIOL_EN 4001: Topics in Biological Engineering

Current and new technical developments in biological engineering.

Credit Hours: 3
Prerequisites: instructor's consent


BIOL_EN 4070: Bioelectricity

(cross-leveled with BIOL_EN 7070). Application of engineering approaches to understand bioelectricity at the cellular level including the equivalent circuit of cell membranes and the electronic design of patch-clamp amplifiers.

Credit Hours: 3
Prerequisites: PHYSCS 2760 and BIOL_EN 3180 or instructor's consent


BIOL_EN 4080: Engineering Computation

(cross-leveled with BIOL_EN 7080). An introduction to numerical methods relevant to biological engineering in the context of scientific computing. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: MATH 4100


BIOL_EN 4085: Problems in Biological Engineering

Supervised independent study at the undergraduate level.

Credit Hour: 1-5
Prerequisites: instructor's consent


BIOL_EN 4150: Soil and Water Conservation Engineering

(same as CV_ENG 4710; cross-leveled with BIOL_EN 7150, CV_ENG 7710). Urban and rural run-off and erosion analysis. Design and layout of erosion control structures.

Credit Hours: 3
Recommended: BIOL_EN 2180 or CV_ENG 3200 or instructor's consent


BIOL_EN 4160: Food Process Engineering

(cross_leveled with BIOL_EN 7160). Study of transport phenomena and unit operations in food processing systems. Emphasis on fluid flow and heat transfer in food processing, preservation processes, refrigeration, freezing, psychrometrics, and dehydration.

Credit Hours: 3
Prerequisites: BIOL_EN 3180 or instructor's consent


BIOL_EN 4170: Biomaterials Interfaces of Implantable Devices

(cross-leveled with BIOL_EN 7170). Surface structures and properties to improve biocompatibility will be studied. Engineering sciences and design will be leverage in the design of an improved biocompatible surface.

Credit Hours: 3
Prerequisites: BIOL_EN 3170 or instructor's consent


BIOL_EN 4231: Transport Phenomena in Materials Processing

(same as MAE 4231; cross-leveled with BIOL_EN 7231, MAE 7231). Applications of fluid flow, heat transfer, and mass transfer in steady-state and unsteady-state materials processing with applications to metals, polymers, and ceramics. Graded on A-F basis only.

Credit Hours: 3
Prerequisites or Corequisites: MAE 4300 or permission of instructor
Prerequisites: MAE 3200, MAE 3400 (or permission of instructor); and MATH 4100


BIOL_EN 4250: Irrigation and Drainage Engineering

(cross-leveled with BIOL_EN 7250). Soil, water, plant relationships. Water supplies and design of surface, sprinkler and drip irrigation systems. Surface and tile drainage.

Credit Hours: 3
Prerequisites: CV_ENG 3700 or MAE 3400 or BIOL_EN 2180


BIOL_EN 4260: Food Process Engineering II

(cross-leveled with BIOL_EN 7260). Continuing study of transport phenomena and unit operations in food processing systems. Emphasis on fluid food evaporation concentration food dehydration, contact equilibrium processes and mechanical separation processes.

Credit Hours: 3
Prerequisites: BIOL_EN 4160 or instructor's consent


BIOL_EN 4270: Design of Experiments and Statistical Quality Control for Process Engineers

(same as CH_ENG 4270; cross-leveled with BIOL_EN 7270, CH_ENG 7270). A practical statistical tool box for experimenters including comparison of process means, effects of variables, design and interpretation of factorial experiments, and statistical quality control.

Credit Hours: 3
Prerequisites: experience with Excel or instructor's consent


BIOL_EN 4280: Survey of Bioengineering Techniques

Laboratory techniques to train students in Bioelectricity, Biomechantronics, Bioenvironment, Biomaterials, Biophotonics, Bioprocessing. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: senior standing


BIOL_EN 4310: Feedback Control Systems

(same as ECE 4310: cross-leveled with BIOL_EN 7310, ECE 7310). System modeling and time and frequency response, closed loop control, stability, continuous system design, introduction to descrete time control, software and hardware experiments on compensator design and PID control. Graded on A-F basis only.

Credit Hours: 4
Prerequisites: MATH 4100 and junior/senior standing. May be repeated for credit


BIOL_EN 4315: Introduction to Bioprocess Engineering

(same as CH_ENG 4315; cross-leveled with BIOL_EN 7315, CH_ENG 7315). This general introduction to bioprocess engineering covers the fundamentals of microbiology and biochemistry in the context of a biomass refinery. Analyses proceed through the use of mass balances, energy balances, and empirical or theoretical models.

Credit Hours: 3
Prerequisites: BIOL_EN 2180 (for Biological Engineering students) or CH_ENG 2225 (for Chemical Engineering students) or instructor's consent


BIOL_EN 4316: Biomass Refinery Operations

(same as CH_ENG 4316; cross-leveled with BIOL_EN 7316, CH_ENG 7316). Design and operation of processes for conversion and/or fractionation of biomass and associated upstream and downstream unit operations. Emphasis on separations and product recovery.

Credit Hours: 3
Recommended: BIOL_EN 2180 or CH_ENG 2225 (for Chemical Engineering students) or instructor's consent


BIOL_EN 4350: Watershed Modeling Using GIS

(same as CV_ENG 4720; cross-leveled with BIOL_EN 7350, CV_ENG 7720). Watershed evaluation using AVSWAT for hydrology, sediment yield, water quality; includes USLE, MUSLE, WEPP. Procedures for model calibration/sensitivity data analysis.

Credit Hours: 3
Recommended: BIOL_EN 2180 or CV_ENG 3200 or instructor's consent


BIOL_EN 4370: Orthopaedic Biomechanics

(cross-leveled with BIOL_EN 7370, V_M_S 7370). Engineering sciences will be leverage to create a comprehensive study of orthopaedic biomechanics. The tissue mechanics of bone and soft tissue will be studied along with applying structural analysis of the musculoskeletal system. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: ENGINR 1200, BIOL_EN 3170, instructor's consent required


BIOL_EN 4380: Applied Electronic Instrumentation

(cross-leveled with BIOL_EN 7380). Fundamental concepts and theories, basic electronics, analog and digital circuits, signal conditioning, computer interfacing, measurement principles and techniques used in developing computer-based instrumentation systems.

Credit Hours: 4
Prerequisites: BIOL_EN 2080 and PHYSCS 2760


BIOL_EN 4420: Introduction to Biomedical Imaging

(same as PHYSCS 4420; cross-leveled with BIOL_EN 7420, PHYSCS 7420). This course offers a broad introduction to medical imaging. Topics to be covered include the physics basics and instrumentation of X-ray CT, PET , SPECT, ultrasound, MRI and Optical Imaging, as well as recent developments in biomedical imaging.

Credit Hours: 3
Prerequisites: PHYSCS 2760


BIOL_EN 4470: Biomolecular Engineering and Nanobiotechnology

(cross-leveled with BIOL_EN 7470). Generation of biotechnological products, devices through integration of engineering approaches with contemporary biology, chemistry and nanotechnology starting at the molecular level. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: senior/graduate standing or instructor's consent


BIOL_EN 4480: Physics and Chemistry of Materials

(same as PHYSCS 4190,CHEM 4490, NU_ENG 4319; cross-leveled with BIOL_EN 7480, PHYSIC 7190, CHEM 7490, NU_ENG 7319). Physics and Chemistry of Materials is a 3 credit hours undergraduate/graduate level course offered every spring semester for students from Physics, Chemistry, Engineering and Medical Departments and consists of lectures, laboratory demonstrations, two mid term and one final exam. Graduate students will submit a term paper.

Credit Hours: 3
Prerequisites: PHYSCS 2760/CHEM 1320 or equivalent/prior approval by instructor


BIOL_EN 4550: Design of Livestock Waste Management Systems

(cross-leveled with BIOL_EN 7550). Development and application of design criteria to the design of agricultural waste management facilities.

Credit Hours: 3
Prerequisites: CHEM 1310 and CV_ENG 3700, MAE 3400 or instructor's consent


BIOL_EN 4570: Fluorescent Imaging

(cross-leveled with BIOL_EN 7570). Principles and applications of fluorescent imaging. The course covers: Image formation in microscope; Fundamentals of fluorescence and fluorescent microscopy; molecular and cellular fluorescent imaging.

Credit Hours: 3
Prerequisites: BIO_SC 1500 and BIOL_EN 2180 or instructor's consent


BIOL_EN 4575: Computational Neuroscience

(same as BIO_SC 4580, ECE 4580; cross-leveled with BIOL_EN 7575, BIO_SC 7580, ECE 7580). An interdisciplinary course with a strong foundation in quantitative science for students in biological-behavioral sciences. Graded on A-F basis only.

Credit Hours: 4
Prerequisites: BIO_SC 1010, BIO_SC 1500; MATH 1500


BIOL_EN 4580: Mechanical Systems Engineering

(cross-leveled with BIOL_EN 7580). Fundamentals and applications of prime movers and power transmissions for the design of engineering systems.

Credit Hours: 3
Prerequisites: Thermodynamics course, Fluid Mechanics course
Corequisites: ENGINR 2100 or BIOL_EN 4380 or instructor's consent


BIOL_EN 4670: Photonics and Nanotechnologies in Optical Biosensors

(cross-leveled with BIOL_EN 7670). Latest applications of photonics and nanotechnologies in optical bio-chemical sensors will be reviewed. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: PHYSCS 2760


BIOL_EN 4770: Biomedical Optics

(cross-leveled with BIOL_EN 7770). Essential concepts and methods for applying optical techniques to biomedical diagnosis and therapy will be covered with major application examples being discussed.

Credit Hours: 3
Prerequisites: PHYSCS 2760 and BIOL_EN 3180; or instructor's consent


BIOL_EN 4870: Molecular and Cell Mechanics

Application of mechanics and engineering principles to biological systems at the cellular and molecular levels. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: ENGINR 2200


BIOL_EN 4940: Engineering Internship

Problem course following prior approved work experience. Problem selected by internship company representative, faculty problem adviser and student. Supervised by faculty problem advisor and presented in engineering report form.

Credit Hour: 2-5
Prerequisites: advisor's consent


BIOL_EN 4980: Biological Engineering Design

Capstone design course for the Biological Engineering major. Design of biological system devices or processes.

Credit Hours: 3
Prerequisites: senior standing or instructor's consent


BIOL_EN 4990: Undergraduate Research in Biological Engineering

Supervised independent study at the undergraduate level.

Credit Hour: 1-5
Prerequisites: instructor's consent


BIOL_EN 4995: Undergraduate Honors Research in Biological Engineering

Open only to honor students in Biological Engineering. Independent investigation in biological engineering to be presented as a thesis.

Credit Hour: 1-5
Prerequisites: advisor's consent


BIOL_EN 7001: Topics in Biological Engineering

Study of advanced developments in biological engineering.

Credit Hour: 1-3


BIOL_EN 7070: Bioelectricity

(cross-leveled with BIOL_EN 4070). Application of engineering approaches to understand bioelectricity at the cellular level including the equivalent circuit of cell membranes and the electronic design of patch-clamp amplifiers. Prerequisites: PHYSCS 2760 and BIOL_EN 3180 or instructor's consent

Credit Hours: 3


BIOL_EN 7080: Engineering Computation

(cross-leveled with BIOL_EN 4080). An introduction to numerical methods relevant to biological engineering in the context of scientific computing.

Credit Hours: 3
Prerequisites: MATH 4100


BIOL_EN 7150: Soil and Water Conservation Engineering

(same as CV_ENG 7710; cross-leveled with BIOL_EN 4150, CV_ENG 4150). Urban and rural run-off and erosion analysis. Design and layout of erosion control structures.

Credit Hours: 3
Prerequisites: BIOL_EN 2180 or CV_ENG 3200, or instructor's consent


BIOL_EN 7160: Food Process Engineering

(cross-level with BIOL_EN 4160).l Study of transport phenomena and unit operations in food processing systems. Emphasis on fluid flow and heat transfer in food processing, preservation processes, refrigeration, freezing, psychometrics, and dehydration.

Credit Hours: 3
Prerequisites: BIOL_EN 3180 or instructor's consent


BIOL_EN 7170: Biomaterials Interfaces of Implantable Devices

(cross-leveled with BIOL_EN 4170). Surface structures and properties to improve biocompatibility will be studied. Engineering sciences and design will be leverage in the design of an improved biocompatible surface.

Credit Hours: 3
Prerequisites: BIOL_EN 3170 or instructor's consent


BIOL_EN 7231: Transport Phenomena in Materials Processing

(same as MAE 7231; cross-leveled with BIOL_EN 4231, MAE 4231). Applications of fluid flow, heat transfer, and mass transfer in steady-state and unsteady-state materials processing with applications to metals, polymers, and ceramics. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: MAE 3200, MAE 3400, MAE 4300 or equivalent; and MATH 4100


BIOL_EN 7250: Irrigation and Drainage Engineering

(cross-leveled with BIOL_EN 4250). Soil, water, plant relationships. Water supplies and design of surface, sprinkler and drip irrigation systems. Surface and tile drainage.

Credit Hours: 3
Prerequisites: CV_ENG 3700 or MAE 3400 or BIOL_EN 2180


BIOL_EN 7260: Food Process Engineering II

(cross-leveled with BIOL_EN 4260). Continuing study of transport phenomena and unit operations in food processing systems. Emphasis on fluid food evaporation concentration food dehydration, contact equilibrium processes and mechanical separation processes.

Credit Hours: 3
Prerequisites: BIOL_EN 7160 or instructor's consent


BIOL_EN 7270: Design of Experiments and Statistical Quality Control for Process Engineers

(same as CH_ENG 7270; cross-leveled with BIOL_EN 4270, CH_ENG 4270). A practical statistical tool box for experimenters including comparison of process means, effects of variables, design and interpretation of factorial experiments, and statistical quality control.

Credit Hours: 3
Prerequisites: experience with Excel or instructor's consent


BIOL_EN 7310: Feedback Control Systems

(same as ECE 7310; cross-leveled with BIOL_EN 4310, ECE 4310). System modeling and time and frequency response, closed loop control, stability, continuous system design, introduction to descrete time control, software and hardware experiments on compensator design and PID control. Graded A-F only. May be repeated for credit.

Credit Hours: 4
Prerequisites: MATH 4100


BIOL_EN 7315: Introduction to Bioprocess Engineering

(same as CH_ENG 7315; cross-leveled with BIOL_EN 4315, CH_ENG 4315). This general introduction to bioprocess engineering covers the fundamentals of microbiology and biochemistry in the context of a biomass refinery. Analysis proceed through the use of mass balances, energy balances, and empirical or theoretical models.

Credit Hours: 3
Prerequisites: BIOL_EN 2180 (for biological engineering students) or CH_ENG 2225 (for chemical engineering students) or instructor's consent


BIOL_EN 7316: Biomass Refinery Operation

(same as CH_ENG 7316; cross-leveled with BIOL_EN 4316, CH_ENG 4316). Design and operation of processes for conversion and/or fractionation of biomass and associated upstream and downstream unit operations. Emphasis on separations and product recovery.

Credit Hours: 3
Prerequisites: BIOL_EN 2180 or CH_ENG 2225 or instructor's consent


BIOL_EN 7350: Watershed Modeling Using GIS

(same as CV_ENG 7720; cross-leveled with BIOL_EN 4350, CV_ENG 4720). Watershed evaluation using AVSWAT for hydrology, sediment yield, water quality; includes USLE, MUSLE, WEPP, Procedures for model calibration/sensitivity data analysis.

Credit Hours: 3
Prerequisites: BIOL_EN 2180 or CV_ENG 3200 or instructor's consent


BIOL_EN 7370: Orthopaedic Biomechanics

(same as V_M_S 7370; cross-leveled with BIOL_EN 4370) . Engineering sciences will be leverage to create a comprehensive study of orthopaedic biomechanics. The tissue mechanics of bone and soft tissue will be studied along with applying structural analysis of the musculoskeletal system. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: ENGINR 1200 and BIOL_EN 3170, instructor's consent required


BIOL_EN 7380: Applied Electronic Instrumentation

(cross-leveled with BIOL_EN 4380). Fundamental concepts and theories, basic electronics, analog and digital circuits, signal conditioning, computer interfacing, measurement principles and techniques used in developing computer-based instrumentation systems.

Credit Hours: 4
Prerequisites: BIOL_EN 2080, PHYSCS 2760


BIOL_EN 7420: Introduction to Biomedical Imaging

(same as PHYSCS 7420; cross-leveled with BIOL_EN 4420, PHYSCS 4420). This course offers a broad introduction to medical imaging. Topics to be covered include the physics basics and instrumentation of X-ray CT, PET , SPECT, ultrasound, MRI and Optical Imaging, as well as recent developments in biomedical imaging, as well as recent developments in biomedical imaging.

Credit Hours: 3
Prerequisites: PHYSCS 2760


BIOL_EN 7470: Biomolecular Engineering and Nanobiotechnology

(cross-leveled with BIOL_EN 4470). Generation of biotechnological products, devices through integration of engineering approaches with contemporary biology, chemistry and nanotechnology starting at the molecular level. Graded on A-F basis only.

Credit Hours: 3


BIOL_EN 7480: Physics and Chemistry of Materials

(same as PHYSCS 7190, NU_ENG 7319, CHEM 7490; cross-leveled with BIOL_EN 4480, PHYSCS 4190, NU_ENG 4319, CHEM 7490). Physics and Chemistry of Materials is a 3 credit hours undergraduate/graduate level course offered every spring semester for students from Physics, Chemistry, Engineering and Medical Departments and consists of lectures, laboratory demonstrations, two midterm and one final exam. Graduate students will submit a term paper.

Credit Hours: 3
Prerequisites: PHYSCS 2760 / CHEM 1320 or equivalent/prior approval by instructor


BIOL_EN 7550: Design of Livestock Waste Management Systems

(cross-leveled with BIOL_EN 4550). Development and application of design criteria to the design of agricultural waste management facilities.

Credit Hours: 3
Prerequisites: CHEM 1310 and CV_ENG 3700, MAE 3400 or instructor's consent


BIOL_EN 7570: Fluorescent Imaging

(cross-leveled with BIOL_EN 4570). Principles and applications of fluorescent imaging. The course covers: Image formation in microscope; Fundamentals of fluorescence and fluorescent microscopy; molecular and cellular fluorescent imaging. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: BIO_SC 1500 and BIOL_EN 2180 or instructor's consent


BIOL_EN 7575: Computational Neuroscience

(same as BIO_SC 7580, ECE 7580; cross-leveled with BIOL_EN 4575, BIO_SC 4580, ECE 4580). An interdisciplinary course with a strong foundation in quantitative science for students in biological-behavioral science. Graded on A-F basis only.

Credit Hours: 4
Prerequisites: BIO_SC 1010, BIO_SC 1500; MATH 1500


BIOL_EN 7580: Mechanical Systems Engineering

(cross-leveled with BIOL_ENG 4580). Fundamentals and applications of prime movers and power transmissions for the design of engineering systems.

Credit Hours: 3
Prerequisites: Thermodynamics course, Fluid Mechanics course
Corequisites: ENGINR 2100 or BIOL_EN 7380 or instructor's consent


BIOL_EN 7670: Photonics and Nanotechnologies in Optical Biosensors

(cross-leveled with BIOL_EN 4670). Latest applications of photonics and nanotechnologies in optical biochemical sensors will be reviewed. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: PHYSCS 2760


BIOL_EN 7770: Biomedical Optics

(cross-leveled with BIOL_EN 4770). Essential concepts and methods for applying optical techniques to biomedical diagnosis and therapy will be covered with major application examples being discussed.

Credit Hours: 3
Prerequisites: PHYSCS 2760 and BIOL_EN 3180; or instructor's consent


BIOL_EN 8000: Scientific Discovery Leading to Life Science Innovations

(same as MPP 8000). The goal of this course is to provide participants with a conceptual and practical understanding of how life science research is conducted in a modern research institution in the US and the pathways involved in translating fundamental discoveries into products and services that affect healthcare. We will cover the transitions from initial discovery concepts to first-in-human studies, clinical trials, healthcare guidelines and policy to product development. We will provide an introduction to essential disciplines and interactions that enable scientific discoveries to move forward into novel device and drug therapies. Participants will come away with a very complete picture of how medical research happens, including: how it is funded; what is required to make discoveries and record and protect intellectual property that is created; how to advance innovations to clinical practice, how to navigate the regulatory and bioethical environment, and how discoveries reach practitioners and benefit patients. The Course is the first in a three course sequence leading to a Graduate Certificate in Life Science Innovation and Entrepreneurship. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: Must be Graduate Standing or receive certificate program director's approval


BIOL_EN 8001: Advanced Topics in Biological Engineering

Study of advanced developments in biological engineering.

Credit Hour: 1-3


BIOL_EN 8085: Problems in Biological Engineering

Supervised individual study at the graduate level.

Credit Hour: 1-99
Prerequisites: departmental consent


BIOL_EN 8087: Seminar in Biological Engineering

Recent investigations in biological engineering and related fields. Discussion of current literature; preparation and presentation of papers.

Credit Hour: 1


BIOL_EN 8088: Advanced Seminar in Biological Engineering

Student presentation and discussion of topical research. May be repeated for credit.

Credit Hour: 1
Prerequisites: BIOL_EN 8087 and BIOL_EN 8402 or instructor's consent


BIOL_EN 8100: Design and Development of Biomedical Innovations

(same as ENGINR 8100). This course takes students through the process of brainstorming and working out a solution to a medical need, and then producing a product. Outputs may include the development of a physical prototype through interactions with the College of Engineering rapid prototype facility. The course is one of a three-course set leading to a Graduate Certificate in Translational Science and Entrepreneurship. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: Student must be enrolled in a graduate degree program and enrolled in a sequenced cohort group beginning with MPP 8000/BIOL_EN 8000 then MPP 8100/BIOL_EN 8100 then MANGMT 8200


BIOL_EN 8150: Natural Systems for Wastewater Treatment

Emphasis is on the design, management and biological performance of lagoons, overland flow systems and constructed wetland.

Credit Hours: 3
Prerequisites: CV_ENG 7230 and BIOL_EN 7150 or instructor's consent


BIOL_EN 8170: Sensors and Biosensors

The course covers basic principles of chemical and biological sensors, such as immobilization techniques, transducers (optical, electrical, etc.) and performance factors.

Credit Hours: 3


BIOL_EN 8180: Numerical Methods in Engineering Research

Numerical techniques and case studies in Biological Engineering. Topics include basic numerical methods, mathematical representation of data, matrix algebra, ordinary and partial differential equations.

Credit Hours: 3
Prerequisites: MATH 4100


BIOL_EN 8230: Advanced Ceramic Materials

(same as CH_ENG 8230, MAE 8230). To provide an advanced level understanding between processing, properties, and microstructure of ceramic materials. Topics include crystallography, defect chemistry, transport properties, microstructure, and forming methods. Graded on A-F basis only.

Credit Hours: 3


BIOL_EN 8250: Water Management Theory

Advanced studies in erosion control, irrigation, and drainage. Water resources engineering.

Credit Hours: 3
Prerequisites: MATH 1500, Computer Engineering and Computer Science course, SOIL 4307 or SOIL 7307 and Soil Conservation course


BIOL_EN 8270: Principles and Applications of Fluorescence

Physical foundations of fluorescence, fluorophores, steady-state and lifetime measurements, and instrumentation. Applications in the life science from tissues staining to DNA probes. Graded on A-F basis only.

Credit Hours: 3


BIOL_EN 8280: Advanced Biological Transport Processes

Principles of fluid flow, heat transfer, and mass transfer applied to (a) understanding of how the human body functions (from the cellular up to the system level) and (b) designing biomedical devices. An independent project/case-study of a relevant research topic also required.

Credit Hours: 3


BIOL_EN 8360: Food Extrusion

Engineering principles and applications of single and twin screw food cooking extrusion systems. Modeling, control and optimization of extrusion systems. Dough rheology.

Credit Hours: 2
Prerequisites: BIOL_EN 7260


BIOL_EN 8370: Materials Characterization Techniques

Concepts and techniques in characterizing materials, including bulk and surface analyses. Techniques are presented in terms of use, sample requirements, and the engineering principles. Topics include: contact angle measurement, XPS, SEM, TEM, STM, AFM, XRD, and thermal analyses.

Credit Hours: 3
Prerequisites: at least one undergraduate course in material science, engineer, or design


BIOL_EN 8380: Modeling and Identification of Engineering Systems

Generalized description of engineering systems, bond graph modeling, system identification techniques, and neural network approaches.

Credit Hours: 3
Prerequisites: MATH 4100


BIOL_EN 8402: Research Methods

(same as F_S 8402). Review of literature; planning research projects; publication procedures.

Credit Hours: 2


BIOL_EN 8470: Ultrasensitive Biodetection

Multiplexing single-molecule, single-cell, nanobiotech analytical techniques to improve disease diagnosis, treatment, and understanding of biophenomena (membrane transport, gene expression, enzyme activities, cell communications). Graded A-F only.

Credit Hours: 3
Prerequisites: Instructor's consent required


BIOL_EN 8570: Microscopic Imaging

Advanced topics in microscopic imaging with focus on applications of molecular and cellular imaging using fluorescent microscopy.

Credit Hours: 3
Prerequisites: BIOL_EN 7570 or instructor's consent


BIOL_EN 8670: Orthopaedic Failure Modes and Effect Analysis

Engineering sciences will be leveraged provide a comprehensive study of failure modes and related effects for orthopaedic devices, orthopaedic tissue repair, and surgical interventions. Clinical case studies will be analyzed to introduce real world problems of orthopaedic failures. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: BIOL_EN 3170 or ENGINR 1200, BIOL_EN 4370 or BIOL_EN 7370 or instructor consent
Recommended: For department majors


BIOL_EN 8770: Photon Migration and Optical Imaging in Turbid Media

The essential concepts and techniques in optical imaging in turbid media will be covered including both forward problems and inverse reconstruction theories. Graded on A/F basis only.

Credit Hours: 3
Prerequisites: instructor's consent


BIOL_EN 8870: Molecular and Cell Mechanics

Application of mechanics and engineering principles to biological systems at the cellular and molecular levels. Graded on A-F basis only.

Credit Hours: 3
Prerequisites: ENGINR 2200


BIOL_EN 8990: Masters Thesis Research in Biological Engineering

Independent investigation to be presented as a thesis. Graded on S/U basis only.

Credit Hour: 1-99


BIOL_EN 9990: Doctoral Dissertation Research in Biological Engineering

Independent investigation to be presented as a thesis. Graded on S/U basis only.

Credit Hour: 1-99