PhD in Microbiology (MED)

Program Overview

The Molecular Pathogenesis and Therapeutic Graduate Program (MPT) was collaboratively designed by the Department of Molecular Microbiology & Immunology (MMI) and the Department of Veterinary Pathobiology (VPB).  The MPT Graduate Program offers a comprehensive graduate program leading to the Doctor of Philosophy (Ph.D.) degree. This program provides individualized training that is strongly oriented toward basic research in molecular and cellular biology, microbial pathogenesis, immunology and host-parasite interactions. Graduates completing this training are prepared to pursue challenging and rewarding professional careers that involve research and teaching at supervisory levels in both the academic and private sectors.

Graduate students entering into the program should be highly motivated toward a career in research in microbiology.  They must have, as a minimum, a baccalaureate degree with an undergraduate record showing superior performance in introductory and advanced coursework in prerequisite subjects (biology, chemistry, physics, and mathematics).  They must have taken the Graduate Record Examination and should have superior scores.  Additionally, international applicants will require demonstration of English fluency via TOEFL scores.  Letters of recommendation from individuals who are qualified to judge should clearly indicate aptitude for, and dedication to, a career in science. 

The MMI and VPB Departments are central components of an interdisciplinary campus eminence program in molecular biology, which also involves molecular biologists in biochemistry and biological sciences as well as many other University departments. Program core facilities provide cell culture and immunology services, DNA sequence analysis, micro array analysis, protein structural analysis, transgenic animals, protein expression, proteomics, electron microscopy and molecular cytology.

Program Degree Options

The Doctor of Philosophy (Ph.D.) Degree

The program involves (i) a course of study which includes required and elective course work, (ii) participation in programmatic seminars and journal clubs, (iii) training in teaching through participation in laboratory courses for undergraduates, (iv) a comprehensive examination designed to evaluate a student’s ability to propose and experimentally evaluate a significant scientific question, and (v) the successful completion of a creative and original scholarly research project.

Degree Options

Ph.D. Degree

On average, the graduate degree program will require four to six years of full-time effort, although this may vary depending on the ability and previous experience of the individual student.  A Master’s Degree is not a prerequisite for the Ph.D. degree.

Dual Degree

A program leading to the combined Ph.D. /M.D. degrees can be designed for students who are admitted to the Medical School and to the MPT Graduate Program.  It is anticipated that these students will fulfill their first two years of Medical School PBL academic requirements before entering the MPT Graduate Program for the research-oriented Ph.D. degree.  All coursework, TA responsibilities, rotations, comprehensive examination and research requirements are the same as for any other graduate student.  Dual degree students will be encouraged to complete research rotations during the summer semesters of their two years of medical curriculum so that a dissertation research project can be initiated immediately upon entering the Ph.D. program.  Typically, clinical responsibilities for the M.D. will be completed after fulfillment of the requirements for the Ph.D.

The Master of Science (M.S.) Degree

Admission to the MPT program as a Masters student is not an option, students are accepted with the intent that they will fulfill the PhD requirements.  Only under unforeseen circumstances  such as illness, a change in academic interest, or other personal reason, is a student allowed  to transfer to the M.S. degree.  Requirements are the same as for doctoral candidates, though successful completion of a comprehensive examination is not a requirement for the Master’s candidate.  Students, opting for a M.S. degree, must complete a research project and write and defend a Master’s thesis in front of their Master’s committee.  The Master’s Committee should consist of at least four faculty members including the mentor.  At least three of the faculty members should be from the MPT Graduate Program and at least one faculty member from outside of the advisor’s primary department.

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Degree Requirements

All students in the program are supported by a stipend (currently $25,000 per year pre- and post-comprehensive exams [taken during 3rd year]) plus tuition costs and basic medical insurance.

Laboratory Rotations

All new graduate students admitted into the MPT Graduate program are required to complete three laboratory rotations starting in the Fall semester and concluding in mid-January before the Spring semester begins. Students will meet with the Director of Graduate Studies prior to each rotation to determine the appropriate laboratory and rotation advisor. Laboratory rotations expose graduate students to research activities within the Program and to the experimental laboratory environment in which they will evolve. Prior to finishing the third laboratory rotation the graduate student selects a mentor. Mentor selection is a mutual agreement between the student and the mentor. Once the mentor has been selected, the student will perform his or her doctoral research under the guidance of the mentor in his/her lab.

Laboratory Rotation Schedule

The MPT Graduate Student Laboratory Rotation Program represents a vehicle to introduce the research laboratory to incoming students and to stimulate a direct interaction between students, faculty and other program personnel.  The program is designed to expose students as quickly as possible to research activities within the Program and to the experimental laboratory environment in which they will evolve.

Laboratory rotations will approximately adhere to the following schedule*:

  • Summer Research Experience** -  Start of Summer semester (usually 1st Monday in June 6th) - July 29th
  • 1st Rotation - August 22nd - October 1st
  • 2nd Rotation - October 3rd - November 12th
  • 3rd Rotation - November 14th - January 13th (this allows limited time off for holidays and final exams)

*These dates will change from year to year depending on the start date of the Fall semester and will be set by the Director of Graduate Studies

**With permission of Director of Graduate Studies, Executive Committee, and Department Chairs

Students who wish to enter the program early at the beginning of the summer semester preceding their first academic semester may do so, if financial resources are available.**   However, this will be considered a “summer research experience” with one of the faculty members but not an official rotation.  This summer research experience should begin no earlier than June 1 and no later than the first day of the Summer semester, and should end on August 15th. This student will still be required to perform the three rotations with different faculty advisors, starting in the fall.  The student would then be able to select one of those advisors including the “summer research experience” advisor as his or her doctoral advisor.   Students engaging in the “summer research experience” will register for 4 credit hrs of Microb 9085 Problems (Rotations) for the summer semester and will need to be on campus by the beginning of the MU summer semester (usually first Monday in June).

Required Courses for Graduate Students in Program

  • Fall semester, 1st year (all required):
  • Three of the following courses (only one of these may be an approved elective):
    • MICROB 9404  Advanced Bacterial Pathogenesis (4 credit hrs.; offered Spring of odd years only)
    • MICROB 9407 Advanced Immunology(4 credit hrs.; offered Spring semesters of even years only)
    • MICROB 9432 Molecular Biology II(4 credit hrs.; offered every Spring semester).
    • MICROB 9449 Infection and Immunity(4 credit hrs.; offered every Fall semester).
    • MICROB 9001 Topics in Microbiology(4 credit hrs.; every other Spring semester of odd years offering as Advanced Virology)
  • Approved 8/9000 current literature-based elective (3-4 credit hrs.)
    8000/9000-level electives:  The DGS and the Curriculum Committee must approve these courses.  They should also be approved  by the student’s doctoral committee (examples of courses still needing approval are given below): 
  • V_PBIO 8641 Introduction to Research Ethics(1 credit hr.; every Spring semester)
  • MICROB 9087 Seminar in Microbiology(required to take this 4 times: 2nd-5th years) (1 credit hr.; every Spring semester)
  • MICROB 9403 Advanced Medical Microbiology (credit for teaching) (2 credit hrs.; every semester)

Other duties

  • Act as a teaching assistant (TA) in MICROB 2800 or MICROB 3200 for two semesters (to be completed during the first two years, but not during the Fall semester of the first year).
  • Attend Program seminars (any invited speakers and student seminars) on Wednesdays at 1:15 pm usually in Monsanto Auditorium in the Bond LSC; attendance will be taken; enroll in MICROB 9087 Seminar in Microbiology for 1 credit hr. in the Spring semesters of years 2-5.  You will need to give a seminar during those years as well, and your grade will be determined by attendance and your presentation.
  • English-Language Proficiency Requirements for International Students

    Any graduate student who completed primary and secondary education (equivalent of K-12 in the U.S.) in a country where English is not the primary language is required by the state of Missouri law to be assessed for English language proficiency. The Speaking Proficiency English Assessment Kit (SPEAK) test is conducted through the Office of Graduate Studies.  International graduate students must receive a level 2 or higher on their language assessment to meet the requirements to TA. If they receive a score below 2 additional courses may be recommended for the student to increase their language skills before their English language is reassessed.

    ONITA training is offered during the week preceding the Fall and Spring semester. The training is required for all new international graduate students before the first semester of teaching or assisting with teaching at MU.

Credit Hour Requirements:

The Graduate School requires 72 hours of advanced study to be completed for the Ph.D. degree.  A minimum of 15 hours of 8000-level course work, not including MICROB 9085 Problems in Microbiology and MICROB 9090 Research in Microbiology, at most, four hours of MICROB 9087 Seminar in Microbiology can count toward this requirement. 

Full-time Student Enrollment

Graduate student full-time enrollment statues pre-comprehensive exam:

  • 9 credit hours for fall and spring, 4 credit hours for summer.

Graduate student full-time enrollment statues post-comprehensive exam:

  • 2 credit hours for fall and spring, 1 credit hour for summer.

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Requirements for Qualifying and Comprehensive Exam

Each student will be required to master two phases of the curriculum, qualifying and advanced, designed to achieve the educational objectives described above.  The MPT Graduate Program Curriculum Committee makes decisions regarding additions or changes to the basic curriculum.  Due to the changing environment in this field of research, the MPT Graduate Program curriculum may be subject to change.

Qualifying Phase

A required basic series of courses are designed to establish a foundation in bacterial pathogenesis (MICROB 7404), virology (MICROB 7303), structure and synthesis of macromolecules (MICROB 7101), and immunology (MICROB 7304). 

Advanced Phase

It is expected that combinations of advanced courses in molecular biology of eukaryotes (MICROB 9432), immunology (MICROB 9407), virology (MICROB 9001), infection and immunity (MICROB 9449), and bacterial pathogenesis (MICROB 9404) will comprise the core curriculum, although alternative courses may be prescribed by the Graduate Student Advisory Committee and by Doctoral committees based upon individual student needs.  Satisfactory performance is defined as a grade of B or above in these 8000/9000 level courses.  Unsatisfactory performance(s) must be corrected according to the recommendations of the Graduate Student Advisory Committee.  Such recommendations may include retaking the course(s), additional examinations, or dismissal from the Graduate Program.

Goals and Purpose of Qualifying and Comprehensive Exams

Qualifying Exam

The goal of this exam is to determine whether the student is qualified to enroll in advanced graduate courses as well as intellectually prepared to perform research in this program.  Passage of the four fundamental required courses implemented in Fall 2013 will constitute passage of the qualifying exam.  The guidelines for this process are covered in greater detail in Section VI of our MPT Graduate Handbook .

Comprehension Exam

The purpose of the comprehensive exam is to certify that the student has sufficient scientific knowledge (from the course work) and research insight to advance to candidacy for the Ph.D.  This knowledge and insight are examined in this program through the student writing and orally defending an NIH-style research grant proposal.  This examination will be administered after the completion of required course work but prior to the end of the student’s third year in the program for students entering the MPT Graduate Program before 2014 or prior to the end of the fall semester of the third year for students entering in 2014 and thereafter.  The guidelines for this process are covered in greater detail in Section VII of our MPT Graduate Handbook.

PhD Dissertation Guidelines

The final education requirement for the Ph.D. degree is the written and oral presentation of a novel and creative piece of scholarly research that represents new information and significantly advances knowledge in that field of research.  The dissertation project must be approved by the student’s doctoral committee and should demonstrate the student’s scientific maturity and ability to write in a scholarly fashion.  At the completion of the dissertation research, the student will present his/her research findings in a public seminar for program faculty and personnel and will defend the project before his/her doctoral committee.  The project will be detailed in a formal written thesis that conforms to Office of Graduate Studies guidelines with respect to format.  Approval of the scientific content of the thesis is the responsibility of each doctoral committee and requires the signature of each committee member, with no more than one dissenting or abstaining vote.  The evaluation will consider the following guidelines with respect to thesis content.

a. Introduction – The manuscript should describe pertinent background material that establishes the foundation for the overall thesis proposed as well as the specific research questions being addressed and the significance of this project with respect to the field.

b. Materials and Methods – The thesis should describe in detail the experimental protocols used in the study; where applicable, references to published protocols should be made, but modifications to such procedures should be defined.  The methods may be presented as a component of each Results chapter, or may be combined into a single, separate chapter.

c. Results – Presentation of the data accumulated during the study that is relevant to the thesis being examined and the conclusions reached.  The data should be presented in chapter format, with each chapter devoted to particular questions relative to the overall thesis.  Since students are encouraged to publish their work during their graduate studies, these chapters may represent those publications (however, the student must be responsible for the writing and presentation of this work in the thesis).

d. Discussion – While each chapter presenting research data may contain a discussion of those specific data, the thesis should be concluded with a summary discussion that presents the student’s overall conclusions about the study and the relevance of this work to the field as a whole.  This summary provides the student an opportunity for knowledgeable speculation as to the significance of the work and its impact on the field.

Program of Study

The program involves satisfactory completion of a minimum of 72 hours of graduate study as well as completion of original research and a thesis, which demonstrates research competence.  Of the 72 hours graduate credit, 15 hours must be in courses numbered 8000/9000 (excluding research and problems courses, but including up to 4 credit hours of seminar courses). 

More information at the MPT Graduate Handbook

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Admissions

Admission Contact Information
Jana Clark
Department of Molecular Microbiology and Immunology 
M616 Medical Science Building
Columbia, MO 65212
573-882-3938
mmi@missouri.edu

The Departments of Microbiology and Immunology in the School of Medicine and Veterinary Pathobiology in the College of Veterinary Medicine have combined, Molecular Pathogenesis and Therapeutics Graduate Program (MPT),  to offer a graduate program designed to prepare students for an advanced professional career in microbiology and immunology. Emphasis is placed on developing outstanding students for productive supervisory roles in universities and colleges, industry, government and research institutes. Enrollment is limited to those students who show evidence of potential for research.

Application Deadline

Fall deadline: January 15

Admission Criteria

  • Minimum TOEFL scores:
Internet-based test (iBT) Paper-based test (PBT)
92 580
Academic International English Language Testing System (IELTS)
6.5
  • Minimum GRE scores:
When did you take the GRE? Verbal + Quantitative Analytical
On or After August 1, 2011 300 3.0
  • Minimum GPA: 3.0
  • Bachelor’s degree from an accredited college or university
  • Courses in the following: biology; advanced courses in biochemistry and/or molecular biology are highly desirable; chemistry (quantitative or organic); physics; mathematics

The PhD degree is offered only to students who demonstrate a high level of specialized knowledge and clear evidence of research potential.

Required Application Materials

To the Office of Graduate Studies:

To the Molecular Pathogenesis and Therapeutics Graduate Program:

  • Departmental application
  • 3 letters of recommendation from individuals competent to comment on the applicant’s potential for graduate work
  • GRE scores
  • Personal statement
  • Copy of TOEFL scores (if international applicant) 

Research & Teaching Assistantships

Students in the doctoral program are awarded research assistantships. Research assistants work with faculty members to obtain practical experience in carrying out research proposals through the collection of research data and writing research reports. All students in the graduate program are required to participate as teaching assistants for two semesters during their graduate studies.

Degree Completion Requirements

To be accepted for candidacy into the PhD program in microbiology & immunology, all applicants must perform satisfactorily in a core curriculum that includes advanced-level courses in the sub disciplines of immunology, molecular biology and microbial pathogenesis. Under the guidance of a doctoral program committee, a course of study is individually designed to fit each student’s academic background, experience and objectives. Interdisciplinary courses in biochemistry, molecular and cellular biology and genetics provide breadth and balance in the program and enhance the student’s research abilities. In addition, the PhD program consists of the following:

  • Practical experience in teaching
  • Successful completion of a comprehensive examination that tests the student’s ability to develop an original scientific hypothesis and devise a feasible research plan that will test the hypothesis.
  • A demonstration of research and writing ability by completing a scholarly dissertation on an approved research problem that results in the contribution of significant new knowledge. The final examination primarily covers this dissertation research.

University of Missouri Graduate School Application:  

“You can apply to the University of Missouri, Office of Research and Graduate Studies or directly to the MPT Program Application and your application will receive equal attention.  However, if you apply through the  MPT Program Application and are accepted by the MPT Admissions Committee you will ultimately have to complete the Graduate School application before you can be formally admitted to the program.  Applicants will not be registered with University of Missouri, Office of Research and Graduate Studies until they have completed the graduate school application and paid the graduate school application fee.”

Applicants who are in the United States and reviewed favorably by the Graduate Admissions Committee will be invited to visit the University of Missouri for an interview for which the program defrays expenses. This visit provides an excellent opportunity for the prospective student to meet the faculty members, talk and interact with our current students, view the University of Missouri-Columbia and the Molecular Pathogenesis and Therapeutics Graduate Program, and experience Columbia, Missouri.

All application materials are filed alphabetically under the family name as indicated by the applicant on the International Student Application form. It is important that all supporting documents use the same name and spelling as the International Student Application so they can be quickly matched up to complete the application file.

You may either print the completed online application form or the PDF version of the form off and mail to:

Jana Clark, Business Support Staff II 
Department of Molecular Microbiology & Immunology
M616 Medical Sciences Building
Columbia, MO 65212

Or e-mail the saved pdf to mmi@missouri.edu

Contact Information:
Chair of Graduate Admission Committee, Roger W. Stich, Ph.D.
Director of Graduate Studies, Michael Calcutt, Ph.D.

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